Establishment of DNA-DNA Interactions by the Cohesin Ring
نویسندگان
چکیده
منابع مشابه
Establishment of DNA-DNA Interactions by the Cohesin Ring
The ring-shaped structural maintenance of chromosome (SMC) complexes are multi-subunit ATPases that topologically encircle DNA. SMC rings make vital contributions to numerous chromosomal functions, including mitotic chromosome condensation, sister chromatid cohesion, DNA repair, and transcriptional regulation. They are thought to do so by establishing interactions between more than one DNA. Her...
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Structural maintenance of chromosome (SMC) complexes are proteinaceous rings that embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC subunits, closed at a pair of ATPase heads, whose interaction is reinforced by a kleisin subunit. Using biochemical analysis of fission-yeast cohesin, we find that a similar series of events facilitates both topological entrapment and...
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Cohesin loops DNA T he glue that holds together sister chromatids also compacts meiotic chromosomes, according to Ding et al. on page 499. This cohesin subunit, called Rec8, seems to tie up chromosomes into loops. The role of Rec8, a meiosis-specifi c cohesin subunit, in chromosome architecture was identifi ed by the authors in a fi ssion yeast screen for meiosis mutants. During meiotic prophas...
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The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids. We report interallelic complementation between pairs of...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.12.021